In my current role, I lead AstraZeneca’s formulation and delivery development activities for therapeutic nucleic acids with a focus on understanding cellular delivery mechanisms of mRNA using non-viral delivery vehicles.

By background, I completed my PhD at the University of Nottingham Doctoral Training Centre in Targeted Therapeutics, where I studied the uptake and intracellular trafficking pathways of polymeric nanop文章s using pH-based nanosensors.

I joined AstraZeneca in 2013 and have been working primarily in the field of nucleic acid delivery since.

I’ve also contributed to various collaborations, to develop nucleic acid based therapeutics including Moderna Therapeutics (mRNA), Ionis (ASOs) and Regulus (anti-miRs).

I joined the Advanced Drug Delivery to help build capabilities for intracellular delivery of nucleic acids. This includes establishing an end to end nanomedicine optimisation platform which advances the design of delivery technologies for applications in gene therapy.
 

I am fascinated by the science of nucleic acids. I believe that addressing the fundamental challenges of intracellular delivery will make a real impact to the therapies of the future.

Arpan Desai Associate Principal Scientist, Advanced Drug Delivery, Pharmaceutical Sciences, R&D

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2019

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2018

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2015

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Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells.永利皇冠登录

Desai AS, Hunter MR, Kapustin A. (2019), Philosophical Transactions of The Royal Society B Biological Sciences, 374. Publication link.

Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin–polyethyleneimine conjugates.永利皇冠登录

Grabowska AM, Kircheis R, Kumari R, Clarke P, McKenzie A, Hughes J, Mayne C, Desai A, Sasso L, Watson SA, Alexander C. (2015), Biomaterials Science, 3(11), 1439-1448. Publication link.

Fluorescent nanosensors for intracellular measurements: synthesis, characterization, calibration, and measurement. 永利皇冠登录

Desai AS, Chauhan VM, Johnston AP, Esler T, Aylott JW. (2013), Frontiers in Physiology, 4: 401. Publication link.