William Dall’Acqua supervises a group in the Department of Antibody Discovery and Protein Engineering, R&D at AstraZeneca.皇冠官网入口
His team of 29 scientists is working on the discovery of new therapeutic antibody drugs and establishing novel antibody technology platforms. In particular, William’s group has developed a novel and ground-breaking strategy to improve the serum half-life of human IgG. Such long-lasting molecules have the potential to make an impact in the field of antibody-based therapy.
William has been studying protein structure, function and engineering for over 20 years and has co-authored over 45 papers and one book chapter in the field. He has also been named inventor on 16 issued patents. He has Bachelor and Masters’ Degrees in Biochemistry from the University of Paris, and a PhD in Immunology from the University of Paris in conjunction with the University of Maryland. He also spent two and a half years as a postdoctoral fellow at Genentech’s Molecular Oncology Department, before joining AstraZeneca.
As soon as we got the early data, it was clear the YTE platform was very robust. We ended up improving the antibody half life by up to 2-4 times.
Enhancement of antibody-dependent cell-mediated cytotoxicity皇冠官网入口
Borrok MJ, Luheshi NM, Beyaz N et al. Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding. MAbs. 2015 4; 7(4):743-51.
Structural Insights into Sifalimumab皇冠官网入口
Oganesyan V, Peng L, Woods RM, Wu H, Dall'Acqua WF. Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab. J Biol Chem. 2015; 290(24):14979-85.
Molecular basis of bispecific antibody's target selectivity皇冠官网入口
Mazor Y, Hansen A, Yang C et al. Insights into the molecular basis of a bispecific antibody's target selectivity. MAbs. 2015; 7(3):461-9.
Improving target cell specificity皇冠官网入口
Mazor Y, Oganesyan V, Yang C et al. Improving target cell specificity using a novel monovalent bispecific IgG design. MAbs. 2015; 7(2):377-89.
Antagonistic activity of anifrolumab皇冠官网入口
Peng L, Oganesyan V, Wu H, Dall'Acqua WF, Damschroder MM. Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody. MAbs. 2015; 7(2):428-39.
FcRn affinity threshold that governs IgG recycling皇冠官网入口
Borrok MJ, Wu Y, Beyaz N et al. pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling. J Biol Chem. 2015 ; 290(7):4282-90.
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